Basic Concepts of Proteomics: The gene transcripts that an individual can make in a lifetime—termed as transcriptome (by analogy with the term genome)—refers to the haploid set of chromosomes carrying all the functional genes. Proteomics has the potential for broad applicability across many areas of medicine and biology and is becoming increasingly widely used in the study of human disease to identify novel biomarkers for use in screening, diagnosis and early detection, and the prediction of therapeutic response (Azad et al. Proteomics is an emerging field that has the potential to uncover new therapeutic targets for the treatment and prevention of cardiovascular disease, as well as new diagnostic biomarkers for early disease detection. Read this article to learn about the basic concepts, technology and applications of proteomics. The area of cardiovascular research has begun to utilise analytical proteomic techniques to evaluate global protein changes in diseased hearts. Further investigation on the applications of advanced proteomics in temperaments, herbal standardization, and … Mass Spectrometry in Proteomics MS has become a powerful tool in proteomics research to precisely determine the molecular mass of peptides and proteins and the sequences. The function of proteins is closely tied to their cellular, tissue and physiological contexts and the protein-protein interactions that drive biological outcomes can be characterized as a fluctuating information flow within the cell and the organism through protein pathways and networks ( 1– 6). 3 Biology applications 3.1 Protein abundance studies. 9, pp. Proteomics, as a powerful tool for systems biology, is an essential research methodology for understanding the mechanisms of traditional medicine. 2006). Quantitative proteomics is playing an important part in this process but there are still some areas in which improvements must be seen before assays are likely to be routinely available to clinicians and patients. Proteomics and its applications Ravi Kumar, PhD 2. Proteomics 1. However, the mechanisms of action of many TCM are still unclear. Application of proteomics to cardiovascular research The discovery of novel proteins, diagnostic biomarkers, and potential drug targets is paramount in the development of new therapeutic agents. 873-881. Medicine has been moving away from a "one-size-fits-all" approach towards predictive, preventive and treatment strategies tailored to the individual - precision medicine. Mass spectrometry represents a powerful technique with a myriad of different applications in biology, chemistry, and physics, but also in clinical medicine and even space exploration. Proteomics • The analysis of the entire protein complement in a given cell, tissue, body fluid and organism • Proteomics assesses activities, modifications, localization, and interactions of proteins in complexes. Molecular medicine is moving beyond genomics to proteomics. 13, No. Click to launch & play an online audio visual presentation by Dr. Joost P. Schanstra on Application of proteomics in fetal and neonatal medicine, part of a collection of multimedia lectures. One of the earliest studies using targeted proteomics absolutely quantified G‐coupled receptor rhodopsin using chemically synthesized peptides as calibration standard to quantify endogenous levels of membrane bound rhodopsin 41. Ethnopharmacological relevance: The rationale for using traditional Chinese medicine (TCM) is based on the experience that has been gained from its wide use over thousands of years. Application of proteomics in research on traditional Chinese medicine. Expert Review of Proteomics: Vol. (2016).